The Garden of Naturalsolution is a leading company in the natural cosmetic ingredients market in Korea.
It specializes in the development and supply of an extensive range of natural ingredients for cosmetic
and food industries since 2004.
|Common name||No common names identified|
|Scientific name||Siegesbeckia glabrescens|
|INCI name||Sigesbeckia Glabrescens Extract|
|Korean Cosmetic ingredient name||진득찰추출물|
|Used part||Whole plant /|
|Potential benefits in cosmetics||anti-acne / anti-inflammatory / anti-bacterial / anti-allergic /|
|Known active compounds||3-O-methylflavones, diterpenes, sesquiterpene lactone|
Siegesbeckia glabrescens is an annual plant known to be used as a traditional medicine in Korea for centuries.The aerial portion and roots of S. glabrescens have been used for the treatment of rheumatic arthritis, asthma,paralysis, hemiplegia, acute hepatitis, osteoporotic fractures, guadriplegia, and allergic disorders.Pharmacological research studies reported that the extracts of S. glabrescens exhibit anti-oxidant, anti-allergic,anti-hypertensive, anti-cancer, and anti-inflammatory activities. Especially, a new compound isolated fromS. glabrescens, 3-(dodecanoyloxy)-2-(isobutyryloxy)-4-methylpentanoic acid, showed anti-bacterial activitiesagainst gram-positive bacteria, such as B. subtilis, E. faecalis, P. acnes, and S. aureus. Flavones and asesquiterpene lactone from S. glabrescens showed anti-inflammatory by inhibiting the production of nitric oxide andprostaglandin E2, decreasing the protein and mRNA levels of inducible nitric oxide synthase and COX-2, andattenuating the DNA transcriptional activity of NF-κB in microglia and LPS-activated RAW 264.7 macrophage cellline. In addition, S. glabrescens has been shown to have anti-allergic activity by inhibiting the production ofimmunoglobulin E (IgE) in LPS-stimulated murine whole spleen cells and human IgE-bearing B cells.