Punica granatum, also known as pomegranate, is native to Persia and is widely cultivated in the Middle East and Asian countries including Iran, Iraq, India, China, Japan, and Korea. The sweet and sour seeds surrounded by a fleshy aril are consumed fresh or as a juice. Pomegranate is a good source of vitamins and polyphenolic compounds such as ellagitannins and flavonoids, which are very powerful antioxidants. Beauty Plus One-F is a natural ingredient from fermented pomegranate fruit processed by Korean Traditional Solid Fermentation. Beauty Plus One-F shows anti-oxidant activity as well as anti-wrinkle activity.