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Newsletter

No.

The Thesis, Antithesis, and Synthesis of Collagen

2023.10.05
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Collagen synthesis is the "thesis" and collagen decomposition is the "antithesis."

When synthesis and decomposition are in harmony,

collagen homeostasis becomes the "synthesis."

This is GNS's beauty formula for skin elasticity.

Collagen! I've heard a lot about it, but how does it work for my skin?

Perhaps you're wondering whether boosting collagen synthesis through external factors is possible. This monthly GNS was created in response to a subscriber's request. We are here to clearly and engagingly demystify collagen.

Our body temperature must remain at a constant 37.5°C to be considered healthy. Similarly, Collagen homeostasis means that collagen synthesis and decomposition are balanced. Maintaining collagen homeostasis allows the collagen network to form. This is the foundation of healthy skin structure.

The delicate balance of collagen synthesis and decomposition can be disturbed by biological aging, UV exposure, and other factors. Skin tissue then loses its elasticity, leading to wrinkles and a dull complexion. Today, excessive sugar consumption contributes to lifestyle diseases. It also contributes to collagen degradation in the skin, and this further complicates collagen homeostasis. Recently, A core focus at GNS is an anti-glycation solution for inhibiting collagen degeneration caused by sugars.

Collagen synthesis begins with three chains. Each consists of a thousand amino acids bound together like strands of hair. These amino acids interweave and twist. They form procollagen and tropocollagen, eventually resulting in the creation of collagen fibers. This complex collagen web provides structural support and tension (much like steel bars in a building's framework). Through extensive research and development, GNS is uncovering natural extracts that both promote procollagen synthesis and increase type 1 collagen production.

Collagen degeneration occurs when excess sugars in the body combine with collagen to produce "Advanced Glycation End Products" (AGEs). When combined with sugar, collagen loses its properties and its structure. This negatively impacts the skin. It leads to wrinkles, reduces skin elasticity, and accelerates skin aging. GNS delves into the anti-glycation effect, continually updating the relevant effective raw materials. This is to inhibit the generation of AGEs by preventing sugar and collagen combination.

Protease MMP-1 (Matrix Metalloproteinase-1) and collagenase play crucial roles in collagen degradation. These degradative enzymes are activated by internal factors (like natural aging) and external factors (like UV exposure and smoking), which disrupt collagen homeostasis. GNS is dedicated to establishing the effectiveness of preserving and protecting existing collagen for extended periods. This can be done by inhibiting the activity of degradative enzymes (especially in the skin where there are concerns about wrinkles and elasticity).

Pomegranate flowers are renowned for their unique blooming patterns. These patterns vary each year because of sensitivity to temperature variations. Male and female flowers differ, and their full blooming is famously elusive. They only bloom for a month some time from mid-May. This makes them even more precious. Pomegranate flowers require patience and meticulous care to cultivate. They are vulnerable to pests and easily damaged by chemical pesticides and fertilizers. The pomegranate fruit has well-known benefits related to preventing aging. Pomegranate flowers, likewise, offer exceptional anti-wrinkle and elasticity-boosting effects. Prolonged UV exposure can rapidly damage collagen in today’s environment. Pomegranate (PD) can serve as a protective shield against collagen damage and the generation of reactive oxygen species.

  • Enhances the expression of enzymes that are crucially responsible for procollagen (P4HA2) and type 1 collagen (COL1A1) production.

  • Thwarts abnormal collagen degradation by inhibiting collagenase (MMP-1) expression and elevating gene expression (TIMP1) to counteract collagenase activity.

  • Amplifies expression of the gene (Fibulin 5) that is crucial for the formation of elastin (an element that interconnects with collagen).

Chamomile is a familiar flower that is widely employed in cosmetics, food, and medicine. Since, at least, Ancient Egypt (circa 2000 BC), it has come to be known as the "doctor plant".

This moniker carries dual significance:

1.It aids plant growth by imparting energy and nutrients to neighboring plants.

2.It serves as a medicinal herb for treating various human ailments.

GNS's Chamomile extract is a versatile raw material. It is adept at enhancing collagen synthesis, inhibiting collagen decomposition, and thwarting protein degeneration caused by glycation.

  • This extract promotes collagen synthesis in the skin by upregulating the gene associated with collagen production (COL1A1).

  • Chamomile extract also exhibits an anti-glycation effect.

  • This effectively inhibits AGEs formation while diminishing Collagenase (MMP-1) expression.

  • P4HA2(Prolyl 4-Hydroxylase Subunit Alpha 2)

    A gene that is pivotal in collagen fiber formation, tissue structure, and procollagen production.

  • COL1A1(Collagen Type I Alpha 1)

    Genes responsible for synthesizing type 1 collagen proteins (the fundamental building blocks of collagen fibers).

  • MMP-1(Matrix Metalloproteinase-1)

    Collagenase (which can result in tissue damage when excessively active).

  • TIMP1(Tissue Inhibitor of Metalloproteinases-1)

    A protein that regulates tissue structure breakdown through MMP-1 inhibition.

  • Fibulin 5

    An essential protein for regulating and interacting with elastin in tissues. It is primarily found in elastic fibers.

  • AGEs(Advanced Glycation End Products)

    The final product of glycation, characterized by an abnormal combination of sugar, protein, and hemoglobin.



The Garden of Naturalsolution
natural03@naturalsolution.co.kr
Seoul, Korea
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