When stress increases, the level of stress hormone (cortisol) increases, which affects skin cells and induces inflammatory reactions. Also, the production of dermal components is suppressed, which leads to a decrease in skin elasticity and accelerated skin aging. In this way, stress management plays an important role in maintaining skin health. Neurocosmetics is an innovative approach that understands and utilizes the connection between stress and skin health. 

Increased stress can increase cortisol levels, and activation of olfactory receptors in the skin can reduce cortisol levels by regulating the secretion of neurotransmitters and hormones. Additionally, it transmits signals to skin cells and contributes to a variety of skin activities, including protecting nerve cells, promoting hair growth, and strengthening the skin barrier.

Salvia officinalis, commonly known as sage or red sage, activates the transduction pathway through olfactory receptors and alleaviates stress reactions by recovering the cell viability that has been affected by cortisol and decreasing the gene expression that has been increased by cortisol.