Portulaca oleracea is an annual succulent with bright yellow flowers surrounded by a cluster of leaves. The plant is known as purslane, little hogweed or pusley, and Machihyun in Korean, meaning ‘horse teeth amaranth’ due to its resemblance to horse’s teeth. It is an edible and nutritious vegetable with a global distribution. It is a well-known plant in Korean traditional medicine, generally used to treat infection and relieve irritated skin. Clinical evaluation has shown that Portulaca Extract-TLS, an extract of P. oleracea, shows excellent skin soothing efficacy.