Lycium chinense is mainly distributed throughout East Asia and particularly throughout southern China, Korea, and Japan. The bright orange-red ellipsoid berry is of the most popular tonic herbs. It has been frequently used in oriental herbal medicine for thousands of years. L. chinensis is rich in vitamins B and C, flavonoids, carotenes, and many other bioactive compounds. Phytoceutical from the stem of L. chinense and shows anti-oxidant, anti-inflammatory, and anti-wrinkle activities. Also, N-feruloyltyramine was identified from L. chinense as one of the active compounds with anti-wrinkle activity.